Research News

The following are noteworthy articles and web resources for information on detection, prevention and treatment of cardiovascular disease.

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Detection of Coronary Artery Disease with a Continuous Infusion of Definity Ultrasound Contrast during Adenosine Stress Real Time Perfusion Echocardiography
Echocardiography (OnlineEarly Articles)
Feng Xie M.D., Jordan Hankins M.D., Heidi A. Mahrous RDCS, Thomas R. Porter M.D.
Summary: Study showing that adenosine stress imaging with real time perfusion echocardiography (RTPE )is an accurate method of detecting coronary artery disease. The higher resolution of RTPE may identify subendocardial defects that would otherwise go undetected with radionuclide imaging.

Arterial Stiffness and Risk of Coronary Heart Disease and Stroke
The Rotterdam Study
Circulation. 2006;113:657-663
© 2006 American Heart Association, Inc.
Francesco U.S. Mattace-Raso, MD, PhD; Tischa J.M. van der Cammen, MD, PhD; Albert Hofman, MD, PhD; Nicole M. van Popele, MD, PhD; Michiel L. Bos, MSc; Maarten A.D.H. Schalekamp, MD, PhD; Roland Asmar, MD, PhD; Robert S. Reneman, MD, PhD; Arnold P.G. Hoeks, PhD; Monique M.B. Breteler, MD, PhD; Jacqueline C.M. Witteman, PhD
Summary: Study to evaluate whether arterial stiffness is a predictor of coronary heart disease and stroke in a population-based study among apparently healthy subjects. Conclusion: Aortic pulse wave velocity is an independent predictor of coronary heart disease and stroke in apparently healthy subjects.

Magnetic Resonance Perfusion Measurements for the Noninvasive Detection of Coronary Artery Disease
(Circulation. 2003;108:432.)
© 2003 American Heart Association, Inc.
Eike Nagel, MD; Christoph Klein, MD; Ingo Paetsch, MD; Sabine Hettwer; Bernhard Schnackenburg, PhD; Karl Wegscheider, PhD; Eckart Fleck, MD
Summary: With MRI, an index of myocardial perfusion reserve (MPRI) can be determined. We assessed the value of this technique for the noninvasive detection of coronary artery disease (CAD) in patients with suspected CAD. The determination of MPRI with MRI yields a high diagnostic accuracy in patients with suspected CAD.;108/4/432

Multislice Computer Tomography for Detection of Coronary Artery Disease
DOI: 10.1111/j.1540-8183.2006.00200.x
Source: Journal of Interventional Cardiology, Volume 19, Number 6, December 2006 , pp. 574-582(9)
Summary: Multislice computer tomography has undergone substantial technological progress during the past years. Current 64-slice scanners with gantry rotation speeds of as little as 330 ms, and particularly the recently introduced dual source CT equipped with two X-ray tubes, provide a temporal and spatial resolution that is sufficient to allow reliable imaging of cardiac morphology and coronary arteries. Especially the ability to noninvasively visualize the coronary arteries, including the assessment and quantification of calcifications, as well as the detection of luminal obstruction and atherosclerotic plaque, constitutes an attractive addition to currently available diagnostic tools for the work-up of patients with known or suspected coronary artery disease. Besides the evaluation of coronary artery calcium and atherosclerotic plaques, this review focuses on the contrast-enhanced CT visualization of the coronary vessels, including native coronary arteries, bypass grafts, and coronary stents.

Detection of coronary artery disease by thallium scintigraphy in patients with valvar heart disease.
British Heart Journal 1986 August; 56(2): 146–151.
H V Huikuri, U R Korhonen, J Heikkilä, and J T Takkunen
Summary: Thallium exercise scintigraphy may be a useful non-invasive test for detecting coronary artery disease in patients with valvar heart disease.

Segmental coronary artery disease: detection by rotating slant-hole collimator tomography and planar thallium 201 myocardial scintigraphy
Radiology, Vol 157, 231-237, Copyright © 1985 by Radiological Society of North America
MR Starling, GJ Dehmer, JL Lancaster, JC Lasher, RA Walsh, FL Weiland, GS Uhl and R Blumhardt
Summary: Compared with qualitative interpretation of the planar and tomographic images, quantitative tomography significantly improved the sensitivity of T1- 201 imaging in detecting LAD, right, and LCx coronary artery disease (P less than .001) in patients with or without previous myocardial infarction.


9/24/2007 - A Prospective Study of Change in Sleep Duration; Associations with Mortality in the Whitehall II Cohort
Researchers from the University of Warwick and University College London have found that lack of sleep can more than double the risk of death from cardiovascular disease. However they have also found that point comes when too much sleep can also more than double the risk of death. In research presented on Monday, September 24, 2007 to the British Sleep Society, Professor Francesco Cappuccio from the University of Warwick’s Warwick Medical School showed the results of a study of how sleep patterns affected the mortality of 10,308 civil servants in the “Whitehall II study”.
Professor Francesco Cappuccio, Warwick Medical School, University of Warwick, Coventry, UK

American Heart Association Journal Report, 05/15/2006 - "Intensive prevention key to fighting coronary artery disease"
American Heart Association/American College of Cardiology scientific statement: "Intensively managing risk factors enhances survival, reduces recurrent events and the need for interventional procedures, and improves the quality of life for coronary heart disease patients, according to new American Heart Association (AHA) American College of Cardiology (ACC) guidelines on secondary prevention." "Heart Attack Prevention Overview"
Authors: Dennis Lee, M.D., Daniel Kulick, M.D., Medical Editor: William C. Shiel Jr., MD, FACP, FACR - Heart Disease Prevention Center, sponsored by AstraZeneca

The Journal of the American Medical Association - Optimal Diets for Prevention of Coronary Heart Disease

U.S. News & World Report - Prevention of Coronary Artery Disease
Developed with the Cleveland Clinic

WebMD - Coronary Artery Disease - Prevention


Cleveland Clinic Heart & Vascular Institute - Coronary Artery Disease Treatment

Cleveland Clinic Heart & Vascular Institute - Coronary Artery Disease Diagnosis and Treatment:
Cardiac Catheterization and Coronary Interventional Procedures (angioplasty and stent)

Mayo Clinic - Treatment of Coronary Artery Disease at Mayo Clinic

General Information Resources

MedlinePlus - A service of the U.S. National Library of Medicine and the National Institutes of Health
Coronary Artery Disease Information Center

Johns Hopkins Medicine - Heart Health Alerts

Texas Heart Institute - Heart Information Center - Coronary Artery Disease

Chest X-Ray - Thoracic Imaging Resources

New England Journal of Medicine Search Page

American Heart Association

American Heart Association Circulation Journal

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